Is Leptin The Key to Weight Loss?


I’ve gotten a ton of requests for a Zenith by Awakend overview. Completely happy New 12 months! Please learn this piece earlier than shopping for Zenith.

Zenith by Awakend is a dietary complement that calls itself a ‘clinically confirmed fats loss accelerator.’

It allegedly works by reducing leptin ranges, which supposedly results in higher communications between fats cells and the mind.

However does it actually?

As with each vitamin MLM (multi stage advertising and marketing) firm, Awakend’s web site is plastered with pictures of skinny, pleased individuals having fun with their lives..all supposedly as a result of they take Zenith.

And look! They’ve an ‘alternative’ for you!

zenith by awakend review
Basic MLM gross sales pitch.

What’s leptin?

We will’t discuss Zenith by Awakend with out first speaking about leptin, its perform, and what best leptin ranges are.

Leptin is a hormone that’s produced by our fats cells. Leptin’s main perform is to control our meals consumption telling the physique to cease consuming when the mind senses that we’ve consumed sufficient energy.

Ghrelin, usually known as ‘the starvation hormone,’ acts reverse to leptin by triggering starvation when our our bodies want energy.

In case you’e ever been on a weight loss plan, you’ve in all probability had the expertise of not with the ability to concentrate on something however meals. That’s ghrelin! Restrictive weight-reduction plan has been proven to extend ghrelin ranges, which basically make meals irresistible. That is the physique’s approach of stopping hunger.

Since leptin is produced by physique fats, people who find themselves overweight usually have excessive leptin ranges. That is paradoxical – if their leptin ranges are excessive, you’d assume that these individuals wouldn’t even get hungry. Nevertheless, elevated leptin in weight problems usually ends in leptin resistance. Identical to in insulin resistance, ranges of the hormone are elevated, however the physique doesn’t ‘see’ them. 

This ends in greater blood leptin ranges, as a result of the fats cells simply preserve pumping out leptin, to no avail. 

In leptin resistance, despite the fact that leptin ranges are excessive, the ‘starvation off change’ of leptin doesn’t work, which leads to the continuation of consuming past what’s bodily essential. This may result in weight achieve and related well being points.

Awakend appears to need individuals to consider that if they’re obese (and even not – most if not all the fashions on their web site look like of regular weight), they’ll cut back leptin and ‘burn fats.’

That’s actually not how any of this works.

In individuals who don’t have leptin resistance, lowering leptin ranges isn’t a desired impact. The truth is, it will possibly make you hungrier – and that is all beneath the idea that Zenith is definitely EFFECTIVE (extra on that in a second).

Once more, it’s like insulin. In case you don’t have insulin resistance, why would you need to mess along with your insulin ranges?

You don’t, belief me.

What’s Zenith by Awakend?

Zenith’s energetic substances are a proprietary combination of cellulose, which is one other phrase for ‘fiber,’ and cetylated fatty acids. These fatty acids have been proven to decreased joint ache in individuals with osteoarthritis, however their effectiveness in fats loss is questionable. 

After I hear that one thing is clinically confirmed, the very first thing I love to do is to examine that out. This implies accessing the analysis that the corporate is basing their declare on, and seeing if it actually does assist what they’re saying.

Zenith by Awakend review
Don’t be fooled by the ‘college performed’ declare, or these impressive-sounding outcomes.

A number of corporations will use sciencey-sounding language and claims to persuade you to purchase their merchandise. It’s vital to have all the knowledge you may get about these items earlier than you resolve to leap in.

The one analysis research that Awakend makes use of to again up its claims is printed proper on their web site, and it doesn’t take lengthy to see that this research is flawed.

I simply need to take the chance proper now to say that weight reduction is NEVER 100% fats, and this declare is absurd.

At first, factor are wanting up for Zenith. The research was a randomized managed trial, which is nice. Each teams misplaced weight throughout the intervention, however the Zenith group seems to have misplaced ‘considerably extra’ weight. Subsequent step on this Zenith by Awakend overview is that we now have to have a look at what meaning.

The research was executed for 8 weeks utilizing 22 girls. All of them had a BMI of over 25, and a median age of 36. Not solely is BMI a horrible metric to evaluate well being (I wrote about BMI right here), however this group can also be not consultant of the overall inhabitants. 

Does Awakend market Zenith solely to girls with a BMI over 25? Nope. It markets it to everybody. And like I mentioned above, discount of leptin isn’t one thing everybody wants. It’s definitely not the holy grail of weight reduction, particularly for individuals who have regular leptin ranges.

Half the themes on this research had been within the placebo group, leaving 11 girls within the complement group. This can be a tiny quantity. Would you’re taking a prescription remedy that was solely examined on 11 individuals? I hope not. And hey – anecdotes and testimonials don’t depend as proof. 

A research executed for 8 weeks doesn’t inform us quite a bit in regards to the efficacy of the product over time. If the complement was so efficient, why didn’t they research it for longer? The research was executed in 2008 – 14 years in the past. There was loads of time to do a peer-reviewed observe up. 

 It’s vital to notice that this research was sponsored by the makers of Zenith’s ‘proprietary method’ (on the time, known as Trisynex). We do must be aware that research which might be sponsored usually tend to have outcomes that favour the consumer.

Once more, if it was so groundbreaking, why in 2023 are we not seeing this product first-line for weight problems and controlled by the FDA?

All topics had been on a reduced-calorie weight loss plan with dietitian counselling and a supervised train program. Is that this constant along with your life? Are you going to work out 4-5x per week with a coach and lower your energy whereas taking Zenith?

The loopy factor is that the research goes on to say that it was probably the fiber within the complement, plus the strenuous train and weight loss plan program, that was chargeable for the elevated weight reduction within the complement group.

If so, why would we even purchase Zenith? Why wouldn’t we simply purchase cellulose powder, on Amazon and simply ignore this overpriced MLM?

Your guess is pretty much as good as mine.

To attempt to rationalize why the cetylated fatty acids might have helped with weight reduction, they cite some research from the early 2000s with unrelated fatty acids, however the reality stays that if any research discovered that any fatty acids had been useful for reducing weight, in 2023 we’d be utilizing them much more usually. As of proper now, they’re relegated to well being meals shops and this firm.

The researchers, till today, don’t have a mechanism for why the cetylated fatty acids in Zenith would work for weight reduction. 

That is all a scorching rubbish mess of unhealthy science. There are simply too many unknowns, coupled with trade sponsorship, a tiny, outdated, and brief research, and tried rationalization utilizing unrelated analysis that doesn’t actually assist Awakend’s trigger in any respect.

Is lowering leptin the key to weight reduction?

As I mentioned earlier, lowering leptin isn’t actually one thing the common particular person ought to aspire to, or fear about. There’s additionally a persistent fantasy that weight reduction is one thing that may be ‘hacked’ with some MLM product that the FDA isn’t sharing with us.

However as we’ve all seen with the brand new GLP-1 agonists like Ozempic, the FDA and mainstream medication do regulate – and earn money off of – weight reduction drugs. No person is hiding something particular – that’s simply what MLM corporations like Awakend need you to consider.

Is Ozempic a superb choice for weight reduction?

There are actually no ‘secrets and techniques’ to reducing weight: all of it comes all the way down to weight loss plan and way of life, in addition to genetics. In case you are obese and have leptin resistance, you could discover your urge for food isn’t satiated. should you shed weight and turn into extra delicate to the leptin your physique produces, this may increasingly enable you eat much less. 

However having what looks like an insatiable urge for food will be the symptom of extra than simply leptin resistance, and it’s vital to think about the opposite causes. They embrace not consuming sufficient protein, not sleeping sufficient, PCOS, and emotional causes reminiscent of rebound consuming ensuing from restriction, and emotional consuming.

Dropping pounds can cut back leptin ranges for overweight people, so something that ends in weight reduction might have this impact. As I at all times say, one of the simplest ways to shed weight is the best way you possibly can follow…and preserve for the long-term. That is typically not a strict train and weight loss plan program coupled by a random complement.

Lastly, and I’ve to say this – MLM merchandise are money-losers for 99% of the individuals who promote them. The multi-level advertising and marketing trade targets girls, chews them up, and spits them out. I wrote all in regards to the risks of MLMs and their ‘coaches’ right here.

Please assume twice earlier than supporting these corporations.

Lengthy-term, significant weight reduction hardly ever occurs with ‘miracle’ merchandise offered by way of MLM. Please don’t fall for them.


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